Disclaimer

The following studies are for informational purposes only. They are not intended to imply that CBD can cure or help any disease. We make no claims, and have added no ‘marketing hype’ to these studies.  Science moves quickly, and a few of the listed studies are old and may have been disproven, or could contain poor science. Some of the studies are animals based which does not necessarily mean the same effect occurs in humans. We have done our best to compile useful information for educational purposes so that you may become a more informed consumer.

If you find any of these studies have been disproven, or contain inaccurate information – please let us know so we can remove it. Conversely, if you have any peer reviewed studies that think should be on the list that we have left out please contact us.

“Phyto-, endo- and synthetic cannabinoids: promising chemotherapeutic agents in the treatment of breast and prostate carcinomas”

“Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells”

Lukhele, Sindiswa T., and Lesetja R. Motadi. “Cannabidiol rather than Cannabis Sativa Extracts Inhibit Cell Growth and Induce Apoptosis in Cervical Cancer Cells.” BMC Complementary and Alternative Medicine 16.1 (2016): 335. PMC. Web. 2 Nov. 2017.b

“Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22 and Nox4 Expression”

“Gamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cells.”

“Inhibition of colon carcinogenesis by standardized Cannabis sativa extract with high content of cannabidiol.”

“Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines”

 “Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy”

“Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis”

McAllister, S.D., Murase, R., Christian, R.T. et al. Breast Cancer Res Treat (2011) 129: 37. https://doi.org/10.1007/s10549-010-1177-4

“Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.”

“Inhibition of colon carcinogenesis by standardized Cannabis sativa extract with high content of cannabidiol.”

“Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines”

“Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy”

“Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis”

McAllister, S.D., Murase, R., Christian, R.T. et al. Breast Cancer Res Treat (2011) 129: 37. https://doi.org/10.1007/s10549-010-1177-4

“Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.”

“Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants”

Hampson, A. J. et al. “Cannabidiol and (−)Δ9-Tetrahydrocannabinol Are Neuroprotective Antioxidants.” Proceedings of the National Academy of Sciences of the United States of America 95.14 (1998): 8268–8273. Print.

“Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity”

El-Remessy, Azza B. et al. “Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-D-Aspartate-Induced Retinal Neurotoxicity : Involvement of Peroxynitrite.” The American Journal of Pathology 163.5 (2003): 1997–2008. Print.

“Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells.”

“The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells.”

“Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine1A Receptor–Dependent Mechanism”

 

“Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.”

“Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis.”

 

“A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management.”

“Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.”

“The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults”

12) Cannabidiol May Promote Heart Health

Study reported that CBD caused dilation of arteries, and protected blood vessel from damage in animal models (R).
CBD reduced the infarct size (size of damage from clogged blood vessels) in the heart and brain, and irregular heart rhythms in animal models (RR2).

Studies showed that CBD reduced the heart rate and blood pressure in response to anxiety or stressful situations (RR2).
CBD also influenced white blood cell function and platelet aggregation (RR2).
However, further work is required to prove the ability of CBD to prevent the development of heart and blood vessels disorders in humans.

13) Cannabidiol May Treat Depression

According to researchers, CBD has antidepressant-like effects in mice (R, R2).
Study found that antidepressant effects of CBD were fast, continuous over time, and comparable to a common tricyclic medication imipramine, also known as Tofranil (RR2).

14) Cannabidiol May Help with Inflammatory Bowel Disease

Studies confirmed that CBD prevents colitis in animal models of IBD (RR2R3).
The combination of CBD and THC may reduce inflammation and relieve symptoms of IBD such as abdominal pain, diarrhea and reduced appetite (R).

Studies also showed that CBD may be a good candidate to normalize gut motility in patients with inflammatory bowel disease (RR2).
CBD may reduce gut inflammation severity through activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) (RR2).

15) Cannabidiol May Protect Against Bacteria

CBD showed some antimicrobial activity against methicillin-resistant Staphylococcus Aureus (MRSA), a bacterium that can cause difficult-to-treat infection (R).

16) Cannabidiol May Protect From Mad Cow Disease

Cannabidiol has been shown to inhibit prions, the proteins that cause fatal neurodegenerative diseases like Creutzfeldt-Jakob disease and mad cow disease, increasing the survival time of infected mice by almost a week (R).

17) Cannabidiol Promotes Bone Growth

Rodents with broken limbs healed much faster when treated with CBD (R).

18) CBD Reduces Dyskinesia

Dyskinesia causes involuntary movements.
CBD (combined with a TRPV-1 blocker) reduces the symptoms of dyskinesiain mice (R).

Mechanisms:

  • CBD reduces the production of inflammatory markers
  • Compared with the reference point, CBD decreased the amounts of key enzymes that can cause dyskinesia (R).
  • CBD, together with a TRPV-1 antagonist, reduces Dyskinesia by acting on CB1 and PPAR gamma receptors and reducing the expression of the inflammatory markers COX-2 and NF-kB (R).

19) Cannabidiol May Help with Insomnia

Research suggests that taking CBD before bed improves sleep in people with insomnia (R).

20) Cannabidiol May be Effective for Treating Substance Use Disorders

Studies suggest that CBD may be therapy for substance use disorders.
CBD reduced the rewarding effects of morphine and reduced drug seeking of heroin in animal model (RR2).

21) Cannabidiol May Help with Quitting Smoking

Research suggests that inhaling cannabidiol for a week might reduce the number of cigarettes smoked by about 40%, without increasing craving for nicotine (R).

22) Cannabidiol May Provide Treatment for Acne

CBD decreases lipid synthesis and proliferation of human sebaceous glands, and has anti-inflammatory effect on sebaceous glands, thus having a potential as a therapeutic agent for the treatment of acne vulgaris (R).

23) Cannabidiol May Play a Role in Psoriasis

CBD reduces the growth of skin cells (keratinocytes), playing a potential role in the treatment of psoriasis (R).